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Title: Digital Membrane Chromatography
Abstract: Electric fields within chromatography membranes provide a third dimension for biomolecule capture, concentration and elution using ion-exchange and affinity membranes. Membranes with a conductive surface permit an electric potential to be applied enabling a reversal of biomolecular charge facilitating elution with multiple cycles. Instantaneous Digital Membrane Chromatography (DMC) reduces dilution and analytical or process time. Molecular degradation resulting from extreme pH is eliminated. Biomolecules with proximal pI’s can be separated.
Author/Presenter: Dr. Stephan Brinke-Seiferth
Title: TBD
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Title: Advanced LC Technologies for Increasingly Complex Molecules
Abstract: Recent advances in drug delivery modalities, such as LNPs, AAVs, and ADCs, have forced scientists to optimize their analytical methodology to keep up with ever-changing critical quality attributes (CQAs). Now, labs are inundated with instrumentation to get the answers they seek. With the ever-changing analyte complexity, Wyatt offers a suite of advanced detection methods and alternative separations to meet these demands and report multiple quality attributes (MQAs). This seminar will address potential solutions for characterization of proteins, peptides, gene therapy using SEC-MALS and FFF-MALS. Case studies for ADC, AOC, and proteins will be presented to illustrate the addition of MALS to standard chromatography.
Author/Presenter: Benjamin Pulminskas is a field application scientist at Wyatt Technology LLC. He obtained his BS in Chemistry from Norwich University in Northfield, VT and MS in Chemistry from Northeastern University in Boston, MA. His research and professional focusses have been in analytical separation methods for proteins and gene therapies. Benjamin joined Wyatt Technology in 2022 and is Wyatt’s subject matter expert on light scattering based out of Atlanta, GA
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